Examples

import numpy as np
import pandas as pd

df = pd.DataFrame({'cost': [350, 250, 200],
                   'revenue': [200, 350, 400]},
                  index=['P', 'Q', 'R'])
df

	cost	revenue
P	350	200
Q	250	350
R	200	400

Control the broadcast axis:

df.ne(pd.Series([200, 400], index=["P", "S"]), axis='index')

	cost	revenue
P	True	False
Q	True	True
R	True	True
S	True	True