Examples
import numpy as np
import pandas as pd
df = pd.DataFrame([
[2, 3, 4, 5],
[6, 7, 8, 9],
[10, 11, 12, 13]
]).set_index([0, 1]).rename_axis(['p', 'q'])
df.columns = pd.MultiIndex.from_tuples([
('r', 't'), ('s', 'v')
], names=['l_1', 'l_2'])
df
df.droplevel('p')
df.droplevel('l_2', axis=1)